Did You Know? Medications and Seizure Threshold

August 2, 2022

Certain medications can lower the seizure threshold and should be used cautiously or avoided in patients with a history of seizures. Risk of seizure can be further increased if: Medication Category Specific Examples Analgesics Tramadol (Ultram), Tapentadol (Nucynta)Meperidine (Demerol)Fentanyl (Duragsic) Antibiotics ImipenemPenicillinsCefepimeFluoroquinolones (eg Ciprofloxacin)IsoniazidLinezolid Antidepressants Bupropion (Wellbutrin)Tricyclics (Imipramine)SSRIs/SNRIs (do not increase risk when used at…