Did You Know? Medication Management to Address Polypharmacy

Sep 27, 2023 | Clinical Insight

Addressing Polypharmacy

Polypharmacy, the concurrent use of multiple medications by a single individual, is a common and concerning issue among older adult patients. As we age, the risk for developing chronic health conditions becomes more common, along with the number of medications used to manage these disease states. Polypharmacy in older adults has been linked to an increased risk for adverse drug events including falls, medication errors, failure to achieve treatment goals through non-adherence, and increased healthcare utilization and cost burden. Medication management strategies, including medication regimen reviews, deprescribing, patient education and monitoring, are vital in reducing the risks associated with polypharmacy and improving medication related outcomes.

How Polypharmacy Develops

  • Aging increases risk of multi-morbidity
  • Multiple medications to manage disease
  • Multiple prescribers
  • Prescribing cascades
  • Failure to deprescribe
  • Self-medicating without communication

Consequences of Polypharmacy

  • Greater healthcare costs
  • Adverse drug events and interactions
  • Complexity and risk for errors
  • Medication non-compliance
  • Increased hospitalization rates
  • Decreased health-related quality of life (HRQOL)
albuterol HFA 902 puffs every 4 hours as needed
aspirin 81 mg1 daily
beclomethasone HFA 402 puffs twice a day
carvedilol 25 mg1 twice daily
chlorthalidone 25 mg1 daily
citalopram 20 mg1 daily
gabapentin 600 mg1 twice daily
insulin glargine 28 units28 units at bedtime
losartan 100 mg1 daily
metformin 1,000 mg1 twice daily
naproxen 500 mg1 twice daily
omeprazole 40 mg1 daily
prednisone 20 mg2 daily
simvastatin 40 mg1 daily
terbinafine 250 mg1 daily for 15 weeks
zolpidem 5 mg1 at bedtime

Polypharmacy – Appropriate vs. Inappropriate

Appropriate Polypharmacy
  • All prescribed medications have a clear therapeutic objective agreed upon with the patient
  • Medications are achieving therapeutic objectives
  • Medications are optimized to achieve benefit while minimizing risk of adverse drug reaction(s)
  • Patient is motivated and able to take all medications as intended
Inappropriate Polypharmacy
  • Indication for medication is no longer applicable to treatment goals
  • Medication is failing to meet therapeutic objective
  • Medication(s) present a high risk for adverse drug events or harmful interactions
  • Patient is unable to take medications as prescribed

Medication Management

Polypharmacy – The simultaneous use of multiple medications to treat diseases and other health conditions.

Impacts of Medication Errors – A medication error is defined as “any preventable event that may cause or lead to inappropriate medication use or patient harm while the medication is in the control of the healthcare professional, caregiver or patient”

Medication Regimen Review – Medication regimen review is a structured evaluation of patient’s medicines with the aim of optimizing medication use to achieve treatment goals.

Deprescribing in Older Adults – Deprescribing is the planned and supervised process of dose reduction or stopping of medication that might be causing harm, or no longer be of benefit. Deprescribing is part of good prescribing, backing off when doses are too high or stopping medications that are no longer needed.

Control of Your Medication List – Maintain and update your medication list (include prescriptions, OTCs, vitamins & supplements). Utilize a single pharmacy, work with your care team to simplify your medication regimen, report any new or unexpected drug-related symptoms


Deprescribing is the process of tapering, stopping, discontinuing, or
withdrawing drugs, with the goal of managing polypharmacy and improving outcomes.
Reducing polypharmacy can help decrease chance of drug interactions, adverse events, falls, improve health outcomes, adherence and patient satisfaction, and decrease healthcare costs.


Deprescribing a Clinical Process: Review All Current Medications. Identify medications to be ceased, substituted or reduced. Plan a Deprescribing Regimen in Partnership with the Patient. Frequently Review and Support the Patient.

Having regular discussions with your medical care team, including your doctor and pharmacist, can help determine when it is appropriate to reassess your medication list and treatment goals. Always consult your medical providers before making changes to how you take your medications, best results are achieved through open communication and interdisciplinary guidance. Deprescribing should only be considered with provider approval and oversight. Additional resources on deprescribing for patients, providers and caregivers are provided below.

Additional Resources

  1. American Geriatrics Society (AGS) – Professional [BEERS Criteria]: https://www.americangeriatrics.org/
  2. American Geriatrics Society (AGS) – Patient & Caregiver: https://www.HealthinAging.org
  3. Deprescribing Algorithms and Educational Workshops: https://deprescribing.org/
  4. Canadian Medication Appropriateness and Deprescribing Network: https://www.deprescribingnetwork.ca/
  5. ASCP/AMDA/AGS Choosing Wisely Campaign: https://www.choosingwisely.org/

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Paul Nolan

As a Consultant Pharmacist, Paul focuses on improving care coordination using best practices to reduce rehospitalizations.

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