Insulin Expiration Dates: an Update

Jun 4, 2021

In the past, we have endeavored to provide LTC caregivers with the most accurate and current information regarding expiration dates of various drugs to avoid any confusion or unsafe practices. Though it has not been that long since we provided an insulin expiration list, there have been some updates and we wanted to provide you with a comprehensive overview/cheat-sheet!

Please note, all insulins should be stored in the refrigerator until opening and protected from light. Once opened or removed from the refrigerator for storage in the medication cart, the insulin should be dated as it will expire in a specified time per manufacturer.

Pens:

Insulin NameExpiration Upon Opening or Removing from Refrigerator
Insulin Glargine U-100 (Lantus, Basaglar, Semglee)28 days
Insulin Glargine U-300 (Toujeo Solostar)56 days
Insulin Detemir (Levemir)42 days
Insulin Degludec (Tresiba)56 days
Insulin Glulisine (Apidra)28 days
Insulin Lispro (Humalog, Admelog, Lyumjev)28 days
Insulin Lispro; Insulin Lispro Protamine (Humalog Mix 50/50 and 75/25)10 days
Isophane Insulin (NPH)-Humulin N14 days
Regular Insulin; Isophane NPH (Humulin 70/30)10 days
Regular Insulin (Humulin R) U-50028 days
Insulin Aspart (Novolog)28 days
Insulin Aspart; Insulin Aspart Protamine (Novolog Mix 70/30)14 days
Isophane Insulin (NPH)-Novolin N28 days
Regular Insulin (Novolin R)28 days
Regular Insulin; Isophane Insulin (NPH) (Novolin 70/30)28 days

Note: With the exception of Tresiba, all pens should be stored at room temperature once opened. DO NOT refrigerate. Once Tresiba is opened, it may be stored in the refrigerator or at room temperature.

GLP-Pens:

NameExpiration Upon Opening or Removing from RefrigeratorStorage of Opened Pen Special Instructions
Byetta30 daysAfter first use, the Byetta Pen injector can be kept at a temperature not to exceed 77 degrees F.
TrulicitySingle use pens. If needed, a single pen may be stored at room temperature not to exceed 86 degrees F for up to 14 days.Single-use pens. Store under refrigeration until use.
Victoza30 daysStore pens that are in use at 59 to 86 degrees F or in a refrigerator at 36 to 46 degrees F. If exposed to temperatures above 86 degrees F, throw the pen away.

Vials:

Insulin NameExpiration Upon Opening or Removing from RefrigeratorStorage of Opened Vial Special Instructions
Insulin Glargine U-100 (Lantus)28 daysMay refrigerate or store at room temperature.
Insulin Detemir (Levemir)42 daysMay refrigerate or store at room temperature.
Insulin Glulisine (Apidra)28 daysMay refrigerate or store at room temperature.
Insulin Lispro (Humalog, Admelog, Lyumjev)28 daysMay refrigerate or store at room temperature.
Insulin Lispro; Insulin Lispro Protamine (Humalog Mix 50/50 and 75/25)28 daysMay refrigerate or store at room temperature.
Isophane Insulin (NPH)-Humulin NPH31 daysMay refrigerate or store at room temperature.
Regular Insulin; Isophane NPH (Humulin 70/30)31 daysMay refrigerate or store at room temperature.
Regular Insulin (Humulin R) 100 units/mL31 daysStore in a cool place.
Regular Insulin (Humulin R) 500 units/mL40 daysMay refrigerate or store at room temperature.
Insulin Aspart (Novolog)28 daysMay refrigerate or store at room temperature.
Insulin Aspart; Insulin Aspart Protamine (Novolog Mix 70/30)28 daysMay refrigerate or store at room temperature.
Isophane Insulin (NPH)-Novolin N42 daysMay refrigerate or store at room temperature.
Regular Insulin (Novolin R)42 daysStore in a cool place (below 25 degrees C [77 degrees F]); do not refrigerate.
Regular Insulin; Isophane Insulin (NPH) (Novolin 70/30)42 daysStore at room temperature; do not refrigerate.

References: Clinical Pharmacology Home (clinicalkey.com). Monographs.  Accessed 5/18/21.

Expirations are all per manufacturer recommendation*

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Brandi VanValkenburg

Brandi provides personalized care as a pharmacy consultant with HealthDirect's northeastern region.  She has been serving our clients for over 10 years. 

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