Ophthalmic Medications

Jul 28, 2021

Did You Know?

From CMS: §483.45(g) Labeling of Drugs and Biologicals and §483.45(h) Storage of Drugs and Biologicals: “Ensure that all drugs and biologicals used in the facility are labeled in accordance with professional standards, including expiration dates.”

It is good standard of practice to date an ophthalmic (eye) medication upon opening. The date upon which a preparation is opened, should be tracked according to the facility policy to reduce the risk of using contaminated drops. The manufacturer’s storage recommendation for each ophthalmic preparation should be reviewed. Manufacturer’s storage recommendations are acceptable. If the manufacturer states a specific expiration date upon opening, this date should be used to determine when to discard the eye preparation. If the manufacturer is unable to provide an expiration date once the medication is opened, current standards of practice generally recommend discarding the eye drop after 28 days because sterility cannot be guaranteed beyond that point.

Other good practices regarding eye drops:

  • Wash hands prior to administration and apply examination gloves.
  • If the eye drop is a suspension, shake well.
  • Remove the cap, taking care to avoid touching the dropper tip. Place the cap on the barrier or a clean, dry
    surface.
  • Never touch the tip of the bottle to the patient, lid, lashes, or surface of the eye.
  • If more than one ophthalmic preparation is administered, please ensure facility policy is followed regarding
    the recommended time that should elapse between each medication. This allows for proper absorption of
    each medication.
  • If an ophthalmic ointment and drop are to be administered, administer the ointment last.
  • Keep the bottle tightly closed when not in use to avoid contamination.

The following charts list several eye medications for which the manufacturer has been contacted to determine an expiration date once opened. This list is not all inclusive. If a medication is not included in the chart below, please review manufacturers’ storage recommendations. For information on manufacturer’s storage recommendations, please refer to: https://dailymed.nlm.nih.gov/dailymed/ or the package insert for each preparation.

ManufacturerDrug NameExpiration Date
AerieRHOPRESSA SOL 0.02%After opening, the product may be kept at 2°C to 25°C
(36°F to 77°F) for up to 6 weeks.
AerieROCKLATAN DROAfter opening, ROCKLATAN can be used until the
expiration date on the bottle.
AkornATROPINE SUL SOL 1% OP
BETAXOLOL SOL 0.5% OP
BETIMOL SOL 0.5%,
CROMOLYN SOD SOL 4% OP
CYCLOPENTOL SOL 1% OP
ERYTHROMYCIN OIN OP
GENTAK OIN 0.3% OP
KETOROLAC SOL 0.5%
KETOTIF FUM DRO 0.025%OP
LEVOFLOXACIN SOL 0.5%
LOTEPREDNOL SUS 0.5%
OFLOXACIN DRO 0.3% OP
PILOCARPINE SOL 1% OP
SOD CHLORIDE SOL 5% OP
TIMOLOL MAL SOL 0.5% OP
THERATEARS SOL 0.25% PF
Good until expiration date on bottle per
manufacturer.
AkornAZASITE SOL 1%14 days
AkornCOSOPT PF SOL 2%-0.5%Store in foil pouch. Once foil pouch is opened, the
vials expire in 15 days.
AkornZIOPTAN DRO 0.0015%Store refrigerated. Expires 30 days from opening the pouch.
AlconBETOPTIC-PILODiscard reconstituted suspension two (2) weeks after combining.
AlconISOPTO ATROP SOL 1% OP
ISOPTO TEARS SOL 0.5% OP
SYSTANE GEL 0.3%
NAPHCON-A SOL OP
4 weeks from opening
AlconGENTEAL GEL 0.3%
GENTEAL TEAR SOL MODERATE
SYSTANE OIN
Good until expiration date on bottle per manufacturer.
AlconSYSTANE SOL6 months after opening or the expiration date on the package, whichever comes first.
AllerganCOMBIGAN SOL 0.2/0.5%28 days
AllerganBLEPHAMIDE SUS OP
FML OIN 0.1% OP
FML FORTE SUS 0.25% OP
LUMIGAN SOL 0.01%
28 days – Manufacturer unable to provide information on expiration date once
opened.
AllerganREFRESH GEL OPTIVE
REFRESH CELL GEL 1% OP
REFRESH LIQU DRO 1% OP
REFRESH P.M. OIN OP
REFRESH PLUS DRO 0.5% OP
90 days from opening
AllerganRESTASIS MUL EMU 0.05%Discard unused emulsion 30 days after opening.
ApotexAZELASTINE DRO 0.05%
BIMATOPROSTSOL 0.03%
OLOPATADINEDRO 0.1%
OLOPATADINESOL 0.2%
28 days
BauschZIRGAN GEL 0.15%14 days
BauschPROLENSA SOL 0.07%16 days
BauschLOTEMAX GEL 0.5%28 days
BauschALREX SUS 0.2%
BEPREVE DRO 1.5%
BRIMONIDINE SOL 0.2% OP
DEXAMETH PHO SOL 0.1% OP
ISTALOL SOL 0.5% OP
LEVOBUNOLOL SOL 0.5% OP
LOTEMAX SUS 0.5%
MURO 128 SOL 5% OP
NEO/POLY/GRA SOL OP
PHENYLEPHRIN SOL 2.5% OP
PRED SOD PHO SOL 1% OP
TIMOLOL GEL SOL 0.5% OP
TIMOPTIC OCU SOL 0.5% OP
TOBRA/DEXAME SUS 0.3-0.1%
30 days
BauschSOOTHE XP DRO31 days
BauschLATANOPROST SOL 0.005%42 days
BauschOPCON-A SOL OP
VYZULTA SOL 0.024%
61 days
BauschLUMIFY DRO 0.025%120 days
BauschBACIT/POLYMY OIN OP
ERYTHROMYCIN OIN OP
MURO 128 OIN 5% OP
NEO/POLY/BAC OIN /HC 1%OP
SOOTHE NIGHT OIN OP
Non-aqueous formulations do not support microbial growth; therefore, it is good
until the expiration date on the bottle.
GreenstoneFLUOROMETHOL SUS 0.1% OP
GENTAMICIN SOL 0.3% OP
KETOROLAC SOL 0.4%
PREDNISOLONE SUS 1% OP
TIMOLOL MALSOL 0.25% OP
28 days
GreenstoneLATANOPROST SOL 0.005%42 days
Hi TechBROMFENAC SOL 0.09% OP
DORZOL/TIMOL SOL 22.3-6.8
DORZOLAMIDE SOL 2% OP
GATIFLOXACIN SOL 0.5%
Good until expiration date on bottle per
manufacturer.
Johnson & JohnsonVISINE MAX SOL RELIEF
VISINE-A DRO
Visine Dry Eye Relief
Can be used throughout the expiration date after
opening.
LeadingCIPROFLOXACN SOL 0.3% OP28 days
MajorLUBRICNT EYE DRO 0.5% OP
NATURAL BAL SOL TEARS
Do not re-use single use containers. Once opened,
if product is being stored according to the label
instructions in original packaging, it should be good
until the marked expiration date on packaging.
MicroDORZOLAMIDE SOL 2% OP28 days
MylanOLOPATADINE DRO 0.1%
TRAVOPROST DRO 0.004%
28 days
NovartisAZOPT SUS 1% OP
BETOPTIC-S SUS 0.25% OP
CILOXAN OIN 0.3% OP
DUREZOL EMU 0.05%
ILEVRO DRO 0.3% OP
PATADAY SOL 0.2%
PAZEO DRO 0.7%
SIMBRINZA SUS 1-0.2%
TOBRADEX OIN 0.3-0.1%
TOBREX OIN 0.3% OP
TRAVATAN Z DRO 0.004%
28 days
PerrigoBACITRACIN OIN OP
NEO/POLY/DEX OIN 0.1% OP
NEO-POLYCIN OIN HC 1%OP
28 days
RisingTIMOLOL MAL SOL 0.25% OP28 days
RugbyARTIFI TEARS OIN OP
ARTIFI TEARS SOL 1.4% OP
NATURES SOL TEARS
Good until expiration date on bottle per
manufacturer.
SandozBETAXOLOL SOL 0.5% OP
BRIMONIDINE SOL 0.15%
CARTEOLOL SOL 1% OP
CIPROFLOXACN SOL 0.3% OP
CYCLOPENTOL SOL 1% OP
DORZOL/TIMOL SOL 22.3-6.8
DORZOLAMIDE SOL 2% OP
KETOROLAC SOL 0.5%
MOXIFLOXACIN SOL HCL 0.5%
NEO/POLY/DEX OIN 0.1% OP
NEO/POLY/DEX SUS 0.1% OP
OLOPATADINE SOL 0.2%
PILOCARPINE SOL 1% OP
POLYMYXIN B/ SOL TRIMETHP
PREDNISOLONE SUS 1% OP
PROPARACAINE SOL 0.5% OP
SULFACET SOD SOL 10% OP
TIMOLOL GEL SOL 0.5% OP
TIMOLOL MAL SOL 0.25% OP
TOBRA/DEXAME SUS 0.3-0.1%
TOBRAMYCIN SOL 0.3% OP
TRAVOPROST DRO 0.004%
Good until expiration date on bottle per manufacturer
SandozLATANOPROST SOL 0.005%Once a bottle is opened for use, it may be stored at room
temperature up to 25°C (77°F) for 6 weeks.
SomersetEPINASTINE DRO 0.05%
TOBRAMYCIN SOL 0.3% OP
30 days
TevaOLOPATADINE SOL 0.2%30 days

Manufacturer’s emails with references available upon request.

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Brandi VanValkenburg

Brandi provides personalized care as a pharmacy consultant with HealthDirect's northeastern region.  She has been serving our clients for over 10 years. 

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